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Biological Application of Dispersive Magnetic Solid Phase Extraction Using Fe3O4@Cuo&GO Nanocomposite and Ion Mobility Spectrometry: Determination of Aspirin

Publish Year: 1402
Type: Journal paper
Language: English
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Document National Code:

JR_IJAC-10-1_009

Index date: 18 November 2024

Biological Application of Dispersive Magnetic Solid Phase Extraction Using Fe3O4@Cuo&GO Nanocomposite and Ion Mobility Spectrometry: Determination of Aspirin abstract

In this study, a dispersive magnetic solid phase extraction (DMSPE) was described by combining graphene oxide (GO) with Fe3O4 and CuO (Fe3O4@CuO&GO) for extraction and preconcentration of aspirin (ASP) in biological samples. The morphology and structure of the prepared nanocomposite was characterized and analyzed by XRD, SEM and FTIR techniques. Ion mobility spectrometry (IMS) method equipped to a corona discharge ionization source was exploited to determine ASA. The extraction parameters (desorption solvent, pH, adsorbent amount, extraction time and temperature) and also the operational parameters of IMS were investigated and optimized. Under the optimum conditions, the DMSPE–IMS method provided a linear range 6.0–40.0 ng for ASA with coefficient of determination R2 = 0.99. The LOD and LOQ values were 0.9 and 3.0 ng for ASA, respectively. The repeatability of developed method was evaluated as relative standard deviation (RSD% = 2.7). The proposed method was also used to determine ASA in human plasma and serum as biological samples, which recovery results were within 89.0–100.0%.

Biological Application of Dispersive Magnetic Solid Phase Extraction Using Fe3O4@Cuo&GO Nanocomposite and Ion Mobility Spectrometry: Determination of Aspirin Keywords:

Nanocomposite , Dispersive magnetic solid phase extraction , Aspirin , Ion Mobility Spectrometry , Biological samples

Biological Application of Dispersive Magnetic Solid Phase Extraction Using Fe3O4@Cuo&GO Nanocomposite and Ion Mobility Spectrometry: Determination of Aspirin authors

Farideh Shamsi

Department of Chemistry, Yazd Branch, Islamic Azad University, Yazd, Iran

Ali Sheibani

Department of Chemistry, Yazd Branch, Islamic Azad University, Yazd, Iran

M. Reza Shishehbore

Department of Chemistry, Yazd Branch, Islamic Azad University, Yazd, Iran