Direct reductive amination of aldehyde compounds using sodium borohydride-Aluminum hydroxide as a novel and selective reduction medium

Reduction is one of the most fundamental and useful reactions in organic synthesis. Sodium borohydride is an inexpensive, safe to handle, environmental friendly and green reducing agent for the reductive amination of aldehydes and ketones. In this work Various carbonyl compounds such as different functionalized aldehydes, were reduced efficiently by NaBH4/Al(OH)3 system under similar reaction condition. The remarkably accelerated rate ofreduction of benzaldehyde and the optimum amounts of products was achieved successfully at room temperature.