Topic: The latest clinical trials of colorectal cancer

Colorectal cancer is one of the most common cancers in the world, which has a high mortality rate today. In order to screen for this cancer, fecal occult blood test (FOBT) and colonoscopy are used. In European and American countries, it is recommended to perform annual FOBT screening program and colonoscopy every 10 years in people over 50 years old, considering that colonoscopy is an invasive method. Fecal occult blood test is more recommended. Occult blood test or FOBT in short is caused by the excretion of blood through stool in small amounts and in an unknown manner and can only be seen by laboratory methods. This blood can diagnose many diseases depending on its origin. If the origin of secret blood from the last part of the digestive system, possibility of colorectal cancer can be concluded from it. Methods : The present study is a systematic review of search engines PubMed Scientific information database and Elmnet and Google Scholar databases Science Direct with the keywords on FOBT, fecal occult blood test ,colorectal cancer . Elsevier time range from 2000 to 2024 was done. From all found articles, 30 articles were selected with the purpose of research Articles that were unavailable or irrelevant were excluded from the study and finally 21 articles were evaluated for review. Results:A test that is performed to detect fecal occult blood from the peroxidase reaction and hemoglobin group is n Various immunochemical methods have been developed to detect fecal occult blood. These methods are specifically for the detection of blood in thelower part of the digestive system of the large intestine. In the laboratories of the universities of medical sciences, the chemical reagents of Meyer and alcohol pyramidine ,guaiac, autolidine and commercial kits for the detection of fecal occult blood are used. According to the representative Meyer, guaiac autolidine is pyrimidine alcohol and commercial kits.Iron-containing compounds increase the activity of peroxidase and vitamin C and antioxidants by slowing down the oxidation process, causing a false negative response. Therefore, as much as possible, the presence of interfering agents should be avoided Stool prevented. Conclusion: FOBT is the most widely used test in colorectal cancer screening. This test is better in terms of cost and availability than other screening methods, although its sensitivity and specificity is lower than colonoscopy, but it has had a significant effect in reducing the death rate caused by this cancer. Statistics show that in America and European countries that implement screening programs among their people on a national basis, compared to countries where such instructions are not implemented. Colorectal cancer has a lower mortality rate. There is no colorectal cancer screening plan in Iran. For this reason, special instructions and trained personnel and awareness programs are not provided to be This causes fewer people to be screened for colorectal cancer

Topic: The latest clinical trials of colorectal cancer Keywords:

ecal occult blood test , cancer , FOBT , Colorectal