The effect of diabetes on fertility an d Epigenetic modification and spermatogenesis

Diabetes is a widespread chronic disease with detrimental effects on male fertility. This study aims toinvestigate the relationship between diabetes and male fertility, focusing on the process ofspermatogenesis and the occurrence of epigenetic modifications. This study was done as a review andlibrary research. For this purpose, the researchers conducted in this field was examined. The resultsshowed that spermatogenesis, the complex process of sperm cell production, is highly sensitive todisturbances in glucose metabolism caused by diabetes. The altered metabolic environment in diabetescan potentially disrupt the development and function of sperm cells. Moreover, emerging evidencesuggests that diabetes can induce epigenetic modifications, which are heritable changes in gene activitywithout altering the DNA sequence. These epigenetic alterations may occur during spermatogenesis,affecting the quality and genetic integrity of sperm cells. Consequently, they can have significantimplications for fertility and the health of offspring. Understanding the mechanisms underlying theimpact of diabetes on male fertility is crucial for developing effective diagnostic and therapeuticstrategies. Further research is needed to elucidate the precise molecular pathways involved in theinterplay between diabetes and spermatogenesis. Additionally, investigating the epigenetic alterationsassociated with diabetes can provide valuable insights into the transgenerational effects on fertility andoffspring health. In conclusion, diabetes exerts considerable influence on male fertility through itseffects on spermatogenesis and the occurrence of epigenetic modifications. This study highlights theimportance of comprehensive management and care for individuals with diabetes to mitigate the adverseeffects on male reproductive health and ensure the well-being of future generations

The effect of diabetes on fertility an d Epigenetic modification and spermatogenesis Keywords:

Diabetes” , “Male fertility” , “Sperm cells” , “Glucose metabolism”.