Synthesis and Characterization of Some New Comarine Azo Chalcones Derivatives to Study Their Cancer Inhibition Activity

This work aincluded the preparation of a new heterogeneous ring compound of azo-chalcone by the ring-closing process using some compounds such as methyl urea, methyl thiaurea, p-amino phenol, 2-dinitrophenyl hydrazine, and naphthalene-2,3-diamine. We prepared penta, hexa, and octa membered ring compounds. Azo dyes have distinctive, attractive colors that vary according to the difference in the groups substituted on the ring. They are prepared by the reaction of nitrosation, presence of contracted hydrochloric acid and 10% NaOH, and finally the formation of diazonium salts and azo dyes. At the end of this investigation, the toxicological activity against two types of cancer, lung cancer, and colorectal cancer were examined. The synthesized compounds are characterized by FTIR and 1H-NMR.

Synthesis and Characterization of Some New Comarine Azo Chalcones Derivatives to Study Their Cancer Inhibition Activity Keywords:

Azo Chalcone , anti-cancer , Heterocyclic compounds , cytotoxic biological