Investigating The Effects Of Cyclophosphamide, Doxorubicin Hydrochloride, Fluorouracil, And Etoposide On c-Myc Protein Expression In Cancer Cells

Objective: This study uses in silico methods to investigate the interactions of four chemotherapy drugs—Cyclophosphamide, Doxorubicin, Fluorouracil, and Etoposide—with c Myc, a protein implicated in cancer progression. The goal is to assess their potential to modulate c-Myc activity, providing computational insights that could inform future experimental strategies for cancer treatment.Methods: Molecular docking simulations were performed using UCSF Chimera and PyRx software to evaluate the binding affinities of the drugs to c-Myc. Data for the c-Myc protein structure and the drug compounds were retrieved from the UniProt and PubChem databases.Results: The results indicated that the drugs showed varying binding affinities toward c-Myc. Notably, Doxorubicin and Etoposide exhibited stronger binding interactions than Cyclophosphamide and Fluorouracil, suggesting that they might have a more pronounced effect on c-Myc activity.Conclusion: These findings highlight the different affinities of the drugs for c-Myc, suggesting that Doxorubicin and Etoposide might have more substantial potential forinfluencing c-Myc activity in cancer therapies. Further studies, including in vitro and in vivo experiments, are needed to validate these interactions and explore their therapeutic relevance in cancer treatment.

Investigating The Effects Of Cyclophosphamide, Doxorubicin Hydrochloride, Fluorouracil, And Etoposide On c-Myc Protein Expression In Cancer Cells Keywords:

Molecular Docking , Cyclophosphamide , Doxorubicin hydrochloride , Etoposide , c-Myc protein