Histopathological changes of spermatogenesis induced by Intra-peritoneal injection of CuO nanoparticles

A number of lifestyle-related factors, including smoking and obesity, as well as a number of environmental factors, such as exposure to dioxins, combustion products, and traffic exhaust gases, appear to have a deleterious influence on the testes and spermatogenesis. Because of its oxidation-reduction (Redox) potential, copper functions as a cofactor in a variety of enzymes that are essential for basic metabolic functions. We assess how copper oxide nanoparticles (CuO-NPs) affected the male reproductive system and the probability of getting pregnant, both of which have not yet been studied. Four groups of creatures were chosen at random. The experimental group received daily doses of 50, 100, and 150 mg/kg of CuO-NPs intraperitoneally (IP). According to the results of the histological investigation, CuO NPs treatment significantly enhanced Sertoli and Leydig cells as well as all testicular germ cells other than spermatozoa at a dose of 100 mg/kg in both the in vivo and in vitro stages. The 150 mg group's spermatids and spermatocytes had significantly decreased as a result of CuO NP's harmful effects during the in vitro phase (P <0.05). We can therefore conclude that a buildup of CuO in high doses may result in a disruption of the CuO homeostasis, which may subsequently reduce male fertility.

Histopathological changes of spermatogenesis induced by Intra-peritoneal injection of CuO nanoparticles Keywords:

Cellular biology , CuO , Nanoparticle , Spermatogenesis