Recent advances in bioglass applications for bone tissue engineering

Synthetic biomaterials are currently used as bone graft substitutes to treat bone disorders. Based on biomechanical properties, these biomaterials are selected to engineer bioactive and bioresorbable scaffolds that increase tissue ingrowth. These porous scaffolds play an important role in new bone formation and vascularization with the ability to incorporate genes, drugs, growth factors, and stem cells. This review focuses on recent advances on bioactive glass materials for bone regeneration. Despite inherent brittleness, bioactive glasses have many promising characteristics for bone engineering scaffolds. Compared to silicate bioactive glasses, borate and borosilicate have the ability to enhance new bone formation .These materials have controllable degradation rates that closely match new bone formation. Interestingly, bioactive glasses can be doped with elements such as Cu, Zn, and Sr, which are advantageous for healthy bone growth. Although bioactive glasses have been examined in detail for bone repair, few investigations have been performed on their applications for repair of soft tissues. A recent work has shown bioactive glass has the ability to promote angiogenesis for healing of soft tissue wounds. In this review, we highlight current advances in the use of bioactive glass materials and their conversion into scaffolds with the essential anatomical shape. Methods used to manipulate the materials’ structures in bone tissue engineering applications and growth factors involved in bone regeneration will be briefly discussed.

Recent advances in bioglass applications for bone tissue engineering Keywords:

Bioactive glass , Tissue engineering , Scaffolds , Bone repair , شیشه زیست فعال , مهندسی بافت , داربست , ترمیم استخوان