Upregulation of the HOXA۱۰-AS۱ LncRNA in Gastric Cancer: An Expression and Bioinformatics Analysis

Background & Objective: Gastric cancer (GC) is a lethal disease with poor prognosis. Long non-coding RNAs (lncRNAs) involved in the development of cancer through changes in their expression levels. In present study, we aimed to evaluate HOXA۱۰-AS gene expression and its potential as a biomarker in GC.Methods: In this study ۶۰ subjects (۳۰ gastric carcinoma tissues and ۳۰ adjacent non-carcinoma tissues) were examined. The expression level of the HOXA۱۰-AS gene was evaluated using quantitative PCR. Furthermore, clinicopathological characteristicswere taken into consideration. Diagnostic value of the HOXA۱۰-AS was examined by ROC curve analysis. Bioinformatics analysis was performed using different databases.Results: Expression of HOXA۱۰-AS was significantly upregulated in GC tumoral tissues. Roc curve analysis revealed that the diagnostic power of HOXA۱۰-AS was high (AUC = ۰.۶۴) in the tumor compared to the normal GC tissues.Conclusion: Our findings show that HOXA۱۰-AS expression level is higher in the GC tumor compared to the adjacent non-carcinoma tissues and can act as a strong diagnostic biomarker in GC patients.

Keywords:

Gastric Cancer , HOXA۱۰-AS , lncRNAs