Optimization of experimental parameters for the determination of amoxicillin by sensitive spectrophotometric method using synthesized gold nanoparticles

Optimization of experimental parameters for the determination of amoxicillin by sensitive spectrophotometric method using synthesized gold nanoparticles abstract

In this study, a sensitive and simple spectrophotometric method has been developed for determination of amoxicillin (AMX) using gold nanoparticles (AuNPs) synthetized by chemical reduction method. This method is based on addition of AMX to AuNPs and nanoparticles aggregation, consequently absorption band of nanoparticles decreased. The optimization of experimental variables was investigated by examining pH, temperature, buffer type and amount, AMX and AuNPs amounts and process time. In the desired condition, the linear calibration graph in the range of 10-250 μg/l was obtained with proper correlation coefficient (R^2=0.99). Limit of detection (LOD) and relative standard deviation (RSD %) were calculated as 0.12 μg/l and 0.61%, respectively. The proposed method was successfully applied to the AMX measurement in pharmaceutical, real water and biological samples.

Optimization of experimental parameters for the determination of amoxicillin by sensitive spectrophotometric method using synthesized gold nanoparticles Keywords:

Spectrophotometry , Amoxicillin , Gold Nanoparticles

Optimization of experimental parameters for the determination of amoxicillin by sensitive spectrophotometric method using synthesized gold nanoparticles authors

Jafar Abolhasani

Department of Chemistry, Faculty of Science, Tabriz Branch, Islamic Azad University, Tabriz, Iran. Corresponding author

Elham Motallebpour Sangestany

Department of Chemistry, Tabriz branch, Islamic Azad University, Tabriz, Iran

Behrouz Vahid

Department of Chemical Engineering, Tabriz Branch, Islamic Azad University, Tabriz, Iran

Certificate
I'm the author of the paper

Export:

Link to this Paper:

https://civilica.com/doc/281486

Document National Code:

JR_JETT-1-4_004

Index date: 29 August 2014

How to cite:

If you want to refer to this Paper in your research work, you can simply use the following phrase in the references section:

Abolhasani, Jafar and Motallebpour Sangestany, Elham and Vahid, Behrouz,1392,Optimization of experimental parameters for the determination of amoxicillin by sensitive spectrophotometric method using synthesized gold nanoparticles,https://civilica.com/doc/281486

در داخل متن نیز هر جا که به عبارت و یا دستاوردی از این Paper اشاره شود پس از ذکر مطلب، در داخل پارانتز، مشخصات زیر نوشته می شود.
برای بار اول: (1392, Abolhasani, Jafar؛ Elham Motallebpour Sangestany and Behrouz Vahid)
برای بار دوم به بعد: (1392, Abolhasani؛ Motallebpour Sangestany and Vahid)
برای آشنایی کامل با نحوه مرجع نویسی لطفا بخش راهنمای سیویلیکا (مرجع دهی) را ملاحظه نمایید.

Scientometrics

The specifications of the publisher center of this Paper are as follows:

Ranking of Islamic Azad University of Tabriz

Type of center: دانشگاه آزاد

Paper count: 19,162

In the scientometrics section of CIVILICA, you can see the scientific ranking of the Iranian academic and research centers based on the statistics of indexed articles.