Mathematical modeling of biodegradable drug delivery systems
Publish place: 07th International Congress on Chemical Engineering
Publish Year: 1390
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
ICHEC07_436
تاریخ نمایه سازی: 25 فروردین 1394
Abstract:
The present study was carried out to develop a general transport-reaction mathematical model for describing simultaneous biodegradation and drug release from drug-loaded biodegradable polymers. To develop proposed model, the water penetration into the devices, catalyzed and un-catalyzed hydrolysis reactions, and monomer diffusion out of the matrices during drug release process was considered, and Fick’s law was used. The developed model are solved numerically. Parametric studies are carried out using the model to demonstrate the effects of catalyzed and un-catalyzed hydrolysis rates on the degradation and drug release rate. Finally, model was fitted to experimental data reported in literature. The results of model computation agreed well with the experimental data.
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Authors
h HeidariP
PDept. Chem. Eng., University of Sistan and Baluchestan, P.O.Box ۹۸۱۶۴-۱۶۱, Zahedan- Iran.
m Khorram
PDept. Chem. Eng., University of Sistan and Baluchestan, P.O.Box ۹۸۱۶۴-۱۶۱, Zahedan- Iran.
a SamimiP
PDept. Chem. Eng., University of Sistan and Baluchestan, P.O.Box ۹۸۱۶۴-۱۶۱, Zahedan- Iran.
n MehranbodP
PSchool of Chemical, Petroleoum and Gas Engineering, Shiraz University, Shiraz- Iran.
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