Hantzsch reaction and quinoxaline synthesis using 1-methyl-3-(2- (sulfooxy)ethyl)-1H-imidazol-3-ium chloride as a new, efficient and BrØnsted acidic ionic liquid catalyst

In this work, the efficiency, generality and applicability of new BrØnsted acidic ionic liquid (BAIL) 1-methyl-3-(2-(sulfooxy)ethyl)-1H-imidazol-3-ium chloride {[Msei]Cl} as heterogeneous and green catalyst for organic transformations are studied. Herein, the following one-pot multi-component reactions in the presence of [Msei]Cl are investigated: (i) the synthesis of quinoxaline derivatives from the reaction of phenylenediamines and 1,2-diketones in EtOHunder mild conditions (room temperature), (ii) the preparation of 1,4-dihydropyridines from onepot multi component condensation of 1,3-dicarbonyl compounds, NH4OAcand aldehydes under solvent-free conditions at moderate temperature (90 °C). High yields, relatively short reactiontimes, efficiency, generality, clean process, simple methodology, low cost, easy work-up, ease of preparation and regeneration of the catalyst and green conditions (in the synthesis of the quinoxaline derivatives) are advantages of the application of [Mesi]Cl as catalyst in the above organic reactions.

Hantzsch reaction and quinoxaline synthesis using 1-methyl-3-(2- (sulfooxy)ethyl)-1H-imidazol-3-ium chloride as a new, efficient and BrØnsted acidic ionic liquid catalyst Keywords:

Hantzsch reaction , quinoxaline synthesis , 1-methyl-3-(2-(sulfooxy)ethyl)-1Himidazol- 3-ium chloride , solid acid , ionic liquid , green chemistry