Study of Diclofenac drug release by PEG/NaY nanocomposites

Recently, hybrid materials using poly ethylene glycol and porous nanocrystal have been developed for drug release. In this study, poly ethylene glycol (PEG)/NaY zeolite nanocomposite get synthesized. This material is characterized using FT-IR spectroscopy, XRD, TGA and SEM. After loading the Diclofenac onto this nanocomposite, the release of Diclofenac was studied in two kinds of release fluids simulating body fluid KH2PO4-NaOHbuffer (pH=7.5) and gastric fluid (HCl aqueous solution, pH=2.5), while controlling the time, pH values, and temperature using UV-Vis. The effect of pH and temperature values on the release amount of loaded-drug was evaluated in different pH (2.5-9) and different temperatures (37-40°C) at certain time intervals by UV–Vis spectrophotometer.Thebehavior of drug release in this nanocomposite is probably due to hydrogen bonding interactions between drug and the hydroxyl group on the composite framework.

Keywords:

PEG/NaY , Diclofenac , Release