Magnetic Iron Oxide/Silica/Albumin Nanocomposite Particles for Drug Delivery and Diagnostics

Combining imaging, targeting and drug delivery functions into one carrier will expand its functionality andprovide in-depth understanding of the delivery mechanism, leading to a better design of drug carrier systems. Magneticnanoparticles are suitable for MR imaging. In this study, magnetite nanoparticles were synthesized by co-precipitationmethod. Silica shell was then coated on magnetite clusters. The surface of these nanocomposite particles wasfunctionalized with an organosilane (EDS) and then albumin attached to the surface of nanocomposite particles to obtaina drug carrier. Characterizations techniques such as X-ray diffraction, scanning and scanning tunneling electronmicroscopy and FT-IR spectroscopy were employed to characterize the as-prepared particles. Results showed that theobtained magnetic nanocomposite particles have promising properties for drug delivery and MR imaging purposes.

Keywords:

Magnetite nanoparticle , Silica , Albumin , Theranostic