Cadmium Telluride Quantum Dots in Conjunction with Luminol Chemiluminescence System as New Analytical Tool for Trace Analysis of Some Antibiotics

A simple and sensitive quantum dots aided chemiluminometric method was described for the determinationof tetracycline (TC) and oxytetracycline (OTC) in their hydrochloride form on the basis of drastic enhancement of thechemiluminescence (CL) from the luminol/L-cysteine-capped CdTe quantum dots (QDs)/sodium periodate system,caused by the presence of TC and OTC hydrochloride. The method uses pH value at which tetracyclines have proven tobe stable. Response surface methodology was exploited for optimizing the experimental conditions. The synthesized QDswere characterized by means of X-ray diffraction (XRD), transmission electron microscopy (TEM), UV-visspectroscopy, and photoluminescence spectroscopy. Under the optimum conditions linear dynamic ranges of 5.0×10-8–6.0×10-6 mol L-1 and 5.0×10-8–8.0×10-6 mol L-1 were observed for TC and OTC, respectively with corresponding detectionlimits of 2.2×10-8 mol L-1 and 3.0×10-8 mol L-1.

Keywords:

Tetracycline , nanoparticles , Chemiluminescence , CdTe quantum dots , Luminol