Mechanical evaluationof poly (3-hydroxybutyrate)/bioactive glass nanocompositescaffoldfabricated by electrospinning for bone tissue engineering

Recently, 3-D nanocomposite scaffolds have shown wide applications in bone tissue engineering forreplacement, regeneration and repair of damaged tissues. In this study, poly (3-hydroxybutyrate) (P3HB)/bioactiveglass (BG) nanocomposite scaffolds with 7.5, 10 and 15 wt% BG nanoparticles were prepared by electrospinningprocess. Scaffolds were characterized by scanning electron microscopy (SEM) and Fourier transform infraredspectroscopy (FTIR). Mechanical properties of the prepared scaffolds were determined by tensile test. BGnanoparticles showed agglomerate formation tendency in more than 10 wt%. SEM images proved interconnectedporous architecture of the scaffolds. FTIR analysis confirmed the interaction of P3HB and BG nanoparticles. Scaffoldscontaining 7.5 wt% of BG nanoparticles demonstrated highest tensile strength. In conclusion, electrospun P3HB/ (7.5wt%) BG nanocomposite scaffold could be used as a candidate for bone tissue engineering.

Keywords:

Bioactive Glass Nanoparticles , Poly (3-hydroxybutyrate) , Tissue Engineering , Electrospinning , Nanocomposite Scaffold