AN EFFICIENT ONE-POT SYNTHESIS OF PHTHALAZINE DERIVATIVES

Aza heterocyclic compounds are major interest for organic chemists because of their mainly pharmacological activities and clinical applications such as antianxiety, antitumor, anticonvulsant, cardiotonic and vasorelaxant. This work a new and efficient synthesis of phthalazine drivatives from the three-component condensation reaction of malononitrile, phthalhydrazine and aromatic aldehydes using CAN mesopros as solid acid catalyst. The features of this procedure are mild reaction conditions, good to excellent yields, short reaction times and operational simplicity

Keywords:

Solvent Free , Phthalazine , Malononitrile , Multi Component , Aza Hetrocyclic