Effect of Systemic Granisetron in the Clinical Course of Spinal Anesthesia with Hyperbaric Bupivacaine for Outpatient Cystoscopy

Background: The goals of this study are evaluation the effect of intravenous (IV) granisetron on the duration of sensory and motor block produced by intrathecal hyperbaric bupivacaine and also post-operative nausea and vomiting in patients undergoing outpatient cystoscopy. Methods: 62 patients, undergoing cystoscopy received either 3 mg IV granisetron or placebo 15 minutes before the spinal block. Sensory and motor block were assessed after the intrathecal injection of bupivacaineevery 2 minutes until the maximum block was achieved and thereafter every 15 minutes until recovery from the sensory and motor block. Results: Demographic data were not statistically different in the study groups. Duration of sensory and motorblock were also not statistically different between the study groups (P = 0.060 and P = 0.070 respectively). No patient in either group had vomiting. Seven patients in saline and zero patient in granisetron group had nausea that was statistically significant (P = 0.040). Time to discharge after surgery was 243 ± 21 and 239 ± 24minutes in granisetron and control group respectively (P = 0.150). Conclusions: Systemic granisetron had no effect on the duration of sensory and motor block produced byspinal anesthesia with hyperbaric bupivacaine. © 2014 Tehran University of Medical Sciences. All rights reserved. Citation: Soltani Mohammadi S, Esmaeili S, Saliminia A. Effect of Systemic Granisetron in the Clinical Course of Spinal Anesthesia with Hyperbaric Bupivacaine for Outpatient Cystoscopy. Acad J Surg, 2014; 1(3): 87-91.

Keywords:

Bupivacaine , Granisetron , Sensory block , Motor block , Anesthesia , Spinal , Outpatients , Cystoscopy