Synthesis,Characterization, Biological Evaluation and anti corrosion activity of some new bis-piperidone Derivatives

Aseries of piperidine derivatives was synthesis by the reaction between substituted benzaldhyde ,pentanone-3,and ammonium acetate by refluxining for 1-2 hr in ethanol and the derivatives refluxed with (4,4'-Diaminodiphenyl sulphone) yielded bispiperidine ,the structures of the synthesized compounds were confirmed by spectroscopy analysis , The reported compounds were screened for their antibacterial activities against : Staphylococcusaureus, Klebsiella,Escherichia coli,pseudomonas aeruginosa,Salmonilla typhi, Enterobacter. The synthesized piperidone-4 were tested to determine their ability to inhibit corrosion of mild steel in 1mol.L-1 H2SO4 and measured by polarization measurements . Which showed that these compounds act as mixed-type inhibitors. The studies revealed that the nitrogen of Schiff base and sulfur atome ,piperidine moiety ,and the phenyl ring assist largely in corrosion control.

Keywords:

piperidones-4 , 4 , 4'-Diaminodipheylsulphone , antibacterialactivity , anticorrosion , polarization , bispiperidine