The study of particle production of polyethylene glycol in Supercritical CO2 , with different molecular weights that are commonly used in the medicinal industry

Supercritical carbon dioxide (CO2) is well established for use as a processing solvent in polymer applications such as polymer modification, formation of polymer composites, polymer blending, microcellular foaming, particle production and polymerization. Also supercritical CO2 has used as a solvent for the generation of particles from poly(ethylene glycol) (PEG) of different molecular weights. Since PEG is a hydrophilic compound, it is a most commonly used polymer for encapsulating a drug. PEG particles with different properties may allow keeping a good control over the release of the drug. In this review common range of molecular weight for medic indusry has studied.it is between 4000 till 10000 .Also, effects of pressure , temperature and nozzle size on particles of PEG has shown . Finally, Solid dispersions in medic industries and PEG as a material used as carrier for solid dispersions in polymeric materials has discussed.

Keywords:

Supercritical carbon dioxide , polyethylene glycol , medic industry , Mohammad Shareei