Cytotoxicity of some 1-(2,4-dihydroxyphenyl)-3-(4-phenylpiperidin-1-yl) prop-2-en-1-one derivatives using MTT assay

Publish Year: 1394
نوع سند: مقاله ژورنالی
زبان: English
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JR_TIPS-1-1_004

تاریخ نمایه سازی: 17 فروردین 1395

Abstract:

Some N-substituted piperidine structures were synthesized and evaluated for cytotoxicity. The N-substituted piperidine with propene substructurecould be considered as a lead structure for furtherstudies of structure activity relationship to develop more potent compounds in future. The compoundswere evaluated against four different cell lines using the standard MTT assay method and doxorubicin was used as the reference drug. The IC50 values weredetermined by constructing dose-response curves and revealed that three of the synthesized compounds were active against breast cancer cell lines. Compound 6a bearing hydroxyl at para position of piperidine ring was the most active compound within this series.

Authors

Farzaneh Fesahat

Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Mehdi Khoshneviszadeh

Department of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran

Alireza Foroumadi

Department of Medicinal Chemistry, School of Pharmacy, and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran

Alireza Vahidi

Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran