In vitro Inhibition of Candida albicans by Streptomyces olivaceus Strain 115

Emergence of Azole-resistant (Candida albicans) is a growing problem worldwide. Searching for new principles is a global need with high priority. With this aim, in vitro anticandidal activity of pure cultures of soil Actinomycetes isolated from Kerman Province were screened against a registered isolate of (C. albicans) (PTCC No. 5027). In comparison with Clotrimazole, the drug of choice of the pathogen, from 50 tested Actinomycetes, crude sap of (Streptomyces olivaceus) strain 115 showed in vitro antagonistic anti-yeast effect on the pathogen. The tests performed aseptically on lawn cultures of the pathogen in well diffusion bioassay system. Inhibitory zones represented complete suppression of (C. albicans). The nature and further biological activity of the active principle are under investigation.

Keywords:

Anticandidal activity , Actinomycete , Streptomyces olivaceus