An efficient One-pot Synthesis of Dihydropyrimidinones using Lcysteine Hydrochloride Catalysts for Biginelli Reaction under Solvent-free Condition.

Multicomponent reactions (MCRs) are receiving increased attention because of their high synthesis efficiency, atom economy molecular diversity, as well as extensive applications in combinatorial chemistry and diversity-oriented synthesis. The Biginelli reaction, one of the most important and useful multicomponent reaction, offers an efficient way to get multifunctional 3, 4-dihydropyrimidin-2(1H)-ones (DHPMs) and related heterocyclic compounds. The great interest in DHPMs stems from the fact that this class of compounds and their derivatives has, in principle, pronounced biological activity. L-Cysteine Hydrochloride acts as an efficient, green and readily available catalyst for the synthesis of 3, 4-dihydropyrimidin-2(1H)-ones. This method, in comparison with the classical Biginelli reaction, has several advantages such as short reaction time, high yields, and easy work-up.

Keywords:

L-Cysteine hydrochloride , Biginelli reaction , solvent-free conditions