An Efficient and Green Synthesis of 3,4Dihydropyrimidinones by an Acidic Functionalized MWCNT

Biginelli reaction is a convenient method for the synthesis of dihydropyridinones, which are important because of their therapeutic and pharmaceutical properties. In this study, acidic functionalized MWCNT was used as a highly efficient and eco-friendly catalyst for the synthesis of 3,4dihydropyrimidinone-2(1H)-one by Biginelli reaction of ethyl acetoacetate, aldehyde and urea under solvent-free conditions. Structurally, Multi-walled carbon nanotubes (MWCNTs) consist of multiple rolled layers of graphene. Three important properties of MWCNTs are the electrical conductivity, the mechanical strength and the thermal conductivity. This method has some advantages such as nontoxic and inexpensive material, low loading of catalyst, clean work up and operational simplicity.

An Efficient and Green Synthesis of 3,4Dihydropyrimidinones by an Acidic Functionalized MWCNT Keywords:

3 , 4 Dihydropyrimidinones2(1H) , Biginelli condensation , MWCNT , Solvent free