Association between pro-inflammatory cytokine gene polymorphism and increased risk gastric cancer
Publish place: 04th National Biotechnology Congress of Iran
Publish Year: 1384
نوع سند: مقاله کنفرانسی
زبان: English
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NBCI04_429
تاریخ نمایه سازی: 30 دی 1386
Abstract:
Interleukin -1beta (IL-1beta) is a pro-informmatory cytokine with multiple biological effects and is synthesized during microbial infection including Helicobacter pylori (Hp) infection with a local increase of IL-1beta expression in the gastric mucosa. Genetic variations in IL-1beta which enhances its production, and its endogenous receptor antagonist (IL-IRN), are associated with increased risk of Hp-associated gastric cancer (GC) development. Polymorphisms such as C/T at - 31 position in IL-1β promoter region harboring the type 2 genotype of IL-IRN are the most important genetic variations in IL-1 gene cluster which is associated with GC occurrence in Hp-infected patients. Molecular genetic studies have shown that carriers of IL-1β-31T have an increased risk of developing gastric cancer with no difference between homozygote and heterozygote individuals. In contrast among different genotypes of IL-IRN, possession of allele2 in mostly associated with an increased risk of GC in homozygote but not in heterozygote. GC cases (n=51) and non GC dyspeptic controls (n=104) were enrolled into this study. Polymorphisms of IL-1beta and IL1-ra were investigated via PCR-CTPP (PCR with Confronting Two-Pair Primers).Host factors were extracted from patient questionnaires and statistical cross tab analusis was performed. Diversity of IL-1β-31T polymorpgisms among GC samples was: 19/6% TT, 66.7% CT and 13.7% CC, and for non GC samples: 28.6% TT, 55.1% CT and 16.3% CC. Frequency of allele 2 IL-1ra in GC and non- GC samples are 64.4% and 7.3% respectively. In this study, there was an associaion founf between blood group distribution and different IL-IRN genotypes (p=0.021). The other factors are similarly distributed among different genotypes of IL-1β-31T and IL-IRN.
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Authors
Maryam Zohri
Biotechnology Research Cenyer, Pasteur Institute of Iran
Clinical team
Cancer Institute, Tehran Medical University
Hamid Reza Vaziri
endoscopy Unit, Mofarrah Hospital
Mohammad Ali Mohagheghi
Cancer Institute, Tehran Medical University