Comparison of expression Septin 14 gene in testis tissue of azoospermic infertile men

The septins are a family of GTPase expressed in a variety of species, ranging from unicellular yeasts to humans. In mammals, 14 septin genes have been identified so far. They have diverse cellular roles including polarity determination, vesicle trafficking, exocytosis and spermatogenesis. Disruption of septin functions has been implicated in the pathology of many diseases, including cancers, neurodegenerative diseases, and male infertility. Here, we study about one of the new members of septin family called septin14 that is specially expressed in testis. SEPT14 maps to 7p11.2 in humans. The objective of the study was to evaluate the mRNA expression of Septin 14 in testis tissue of infertile azoospermic men.

Keywords:

Septin14 , Spermatogenesis , Male infertility , Azoospermic