Investigation of Gas6 gene expression in colorectal cancer
Publish Year: 1394
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
NCNCMB02_079
تاریخ نمایه سازی: 12 تیر 1395
Abstract:
It is widely accepted that CRC develops via a series of genetic and epigenetic changes that lead to the transformation of normal mucosa into a premalignant polyp, and ultimately to a malignancy. Colorectal cancer incidence rates by stage show relatively steady trends over the 7-year period.About one-third of patients diagnosed with (CRC) have a family history of cancer, placing them and other family members at elevated risk for this disease. Change in bowel habits, general or localized abdominal pain, weight loss without other specific causes, weakness, iron deficiency and anemia are the most common symptoms, and depends on the location and stage of the primary tumor. Altered activity or expression of GAS6/TAM components has been detected in a variety of anthologies such as inflammation, coagulopathy, cancer, autoimmune disease, diabetic vascular disease, kidney disease, and chronic kidney failure.
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Authors
leila yamini
Department of Genetics,Science and Research Branch, Islamic Azad University, Zanjan,Iran
shirkoohi reza
Imam Khomeini Hospital Complex , Cancer Institute, Department of Genetics, Tehran University of Medical Sciences, Tehran, Iran
sina mirzaahmadi
Department of Genetics, Zanjan Branch, Islamic Azad University, Zanjan ,Iran