Designing the analog of cyclic peptide cyclosaplin, cyclosaplin-7R, and determining anti tumor activity with bioinformatical perspectives

Conventional cancer therapies mainly focus on mass cell killing without high specificity and often cause severe side effects and toxicities. Peptides are a novel class of anticancer agents that could specifically target cancer cells with lower toxicity to normal tissues, which will offer new opportunities for cancer treatment. Recently, a Small cyclic peptides cyclosaplin exhibited potent biological activity have great potential for anticancer therapy. In this study, a novel peptide, cyclosaplin-7R designed according to the structure, charge, hydrophobicity,helixicity and SVM parameters. Also we investigated the antitumor activity of cyclosaplin-7R by Anticp software . Moreover, our bioinformatical studies showed that cyclosaplin-7R had great anticancer activity while some in-vitro experiments against some immortalized cell line (MDA-MB-231) must be performed in next of this study. In conclusion, cyclosaplin-7R could be a new effective drug for cancer research as much as cyclosaplin.

Keywords:

cyclosaplin-7R , anti tumor activity , bioinformatic study