New research has shown that cannabis could act as effective anti-cancer agents

It is well-established that cannabinoids exert palliative effects on some cancer-associated symptoms. In this review we will summarize these potential clinical benefit of using cannabinoids in anticancer therapies and will discuss the possible future avenues of research in this area. We did a systematic review of 41 studies identified by searching PubMed, Ovide, Elsevier, ProQuest, IranMedex, SID, and Magiran. All studies included nutrition affects related to promotion of life consent, Sexual dysfunction betterment and confidence in patients with spinal cord injury. Cannabinoids are the bioactive components of the Cannabis plant that display a diverse range of therapeutic qualities. We explored the activity of six cannabinoids, used both alone and in combination in leukaemic cells. Cannabinoids were cytostatic and caused a simultaneous arrest at all phases of the cell cycle. Cannabinoids have been shown to activate an ER-stress related pathway that leads to the stimulation of autophagy-mediated cancer cell death. In addition, cannabinoids inhibit tumor angiogenesis and decrease cancer cell migration. The mechanisms of resistance to cannabinoid anticancer action as well as the possible strategies to develop cannabinoid-based combinational therapies to fight cancer have also started to be explored. Cannabinoids exert palliative effects in cancer patients by preventing nausea, vomiting and pain and by stimulating appetite. In addition, these compounds have been shown to inhibit the growth of tumour cells in culture and animal models by modulating key cell-signalling pathways. Cannabinoids are usually well tolerated, and do not produce the generalized toxic effects of conventional chemotherapies. Cannabinoids is used in anticancer therapies and we suggest that the activities of some cannabinoids are influenced by treatment schedules; therefore, it is important to carefully select the most appropriate strategy in order to maximize their efficacy.

Keywords:

Cannabinoids , Cancer , Anticancer therapies