Effect of alcoholic extract of grape (Vitis Vinifera) on wound healing diabetic male Wistar rats

Introduction: Finding effective drugs have been considered for healing diabetic wounds by researchers. The purpose of this study was to evaluate the effect of alcoholic extract of grape (Vitis Vinifera) on wound healing diabetic male Wistar rats. Materials and methods: In this study 48 male Wistar rats were divided into four groups (negative control, positive control, the first experimental, the second experimental). A wound with 3 cm length was created on the left side of the spinal cord's skin in all groups. The wound healing was evaluated microscopically. The results reported as Mean ± SD. Statistical inference border were (P ≥0/05) and (P ≥0/01) and (P ≥0/001). Results: Wound healing in diabetic groups was later compared with the normal group and wound healing in experimental groups treated with Vitis Vinifera was quicker than the control group, respectively. Conclusion: In this study, results showed that Vitis Vinifera accelerated the wound healing in normal and diabetic samples.

Keywords:

Wound healing , Alcoholic extract of grape (Vitis Vinifera) , Diabetic rat