Nerinine and Homolycorine: Amaryllidaceae Alkaloids from the Bulbs of Galanthus transcaucasicus Fomin

Publish Year: 1395
نوع سند: مقاله کنفرانسی
زبان: English
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تاریخ نمایه سازی: 25 آذر 1395


The main aims of this study was the identification of alkaloid compounds from Galanthustranscaucasicus Fomin, a medicinal plant belong to Amaryllidaceae. A particularcharacteristic of Amaryllidaceae is a consistent presence of an exclusive group of alkaloids,which have been isolated from the plants of all the genera of this family.Planar and column chromatography techniques were used for isolation of alkaloid components.GC/MS analysis was carried out for the identification of alkaloid compounds. Results: Silica gelcolumn chromatography of the alkaloidal extract of G. transcaucasicus afforded seven fractions.Preparative thin layer chromatography of these fractions led to the isolation of compounds 1(Nerinine) and 2 (Homolycorine) and 3 (bicyclo[2.2.2]oct-2-ene, 1-methylamino). Galantaminewas not detected in any of these fractions .Our findings showed that G. transcaucasicus couldhave different chemo-types and be a new source of bioactive alkaloids for possible applicationsin pharmaceutical industries.


Marzieh Babashpour-Asl

Department of Horticultural Sciences, Faculty of Agricultural Sciences, University of Guilan, Rasht, Iran

Hossein Nazemiyeh

Research Center for Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tabriz University of MedicalSciences, Tabriz, Iran.

Hedayat Zakizadeh

Department of Horticultural Sciences, Faculty of Agricultural Sciences, University of Guilan, Rasht, Iran

Alireza Motallebi-Azar

Department of Horticultural Sciences, Faculty of Agriculture, Tabriz University, Tabriz, Iran

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