Nano Ni: As an efficient catalyst for the one-pot synthesis of 3, 4-dihydropyrimidin-2- (1H)-ones derivatives under thermal and solvent-free conditions

In This protocol, we have reported Nano Ni as an efficient and environmentally benign nature catalyst for the one-pot three-component Biginelli synthesis of 3,4-dihydropyrimidin-2- (1H)- ones derivatives via β-keto esters, aldehyde derivatives and urca/thiourea under thermal and solvent-free conditions with short reaction times and excellent yields. The most benefits this procedure is such as inexpensive and non-toxic catalyst, eco-friendly, solvent-free conditions, simple operational procedures, enivironmentally benign nature, one- pot, ecxellent yields.

Nano Ni: As an efficient catalyst for the one-pot synthesis of 3, 4-dihydropyrimidin-2- (1H)-ones derivatives under thermal and solvent-free conditions Keywords:

Nano Ni , 3 , 4-Dihydropyrimidinone , Biginelli reaction , multi component , synthesis