Construction of selective potentiometric sensor for Isoniazid by modified carbon paste electrode with Iron magnetic nanoparticles

Isoniazid (pyridine-4-carboxilic acid hydrazide or isonicotinic acid hydrazide) is a widely used drug alone in the prophylaxis and in combination with other anti tuberculars in the treatment ofall forms of tuberculosis [1]. Several methods for the analysis of isoniazid are available in the literature. [2,8]. On the other hand, applications of potentiometric sensors in the field of pharmaceutical and biomedical analysis have been advocated [9]. Potentiometric detection based on ion-selective electrodes (ISEs), offers several advantages such as speed and ease of preparation and procedures, simple instrumentation, relatively fast response, wide dynamic range, reasonable selectivity, and low cost [10]. In this paper, we introduced new potentiometric sensors for selective determination of Isoniazid in pharmaceutical preparations and biological fluids.

Construction of selective potentiometric sensor for Isoniazid by modified carbon paste electrode with Iron magnetic nanoparticles Keywords:

Isoniazid , Nanoparticles , CPE , ISEs , Potentiometric