The mechanism of miR-21 in OSCC

Oral squamous carcinoma cancer (OSCC) is the most common types of head and neck cancer(HNSCC). OSCC the sixth solid cancer in worldwide. With convenient access to examinationand biopsy of cancerous tissue, causing people are high mortality is diagnosed in advancedstages of OSCC. According to reliable molecular markers that provide early detection OSCC,Prognosis Prediction and they are dedicated to treating patients. With this commentary, smallnon-coding RNA can play a role in cancer detection.Mir-21 in OSCC promoting effects,microRNA are able to regulate gene expression down. Mir-21 on the differentiation, diversity,apoptosis and metastasis plays a role. Target linked to the miR-21 extracted from the target scandatabase. And mechanisms related to targets of miR-21 with genetrail 2 were checked. In Gobiological process detected of the similarity between cancer cells and embryonic cells wereclearly marked.By focusing impact mir-21, receptor PDCD4 arrived in OSCC‘s invasion,metastasis and differentiation. After more studies can be used to identify other receptors to treatand diagnose OSCC, to be inhibited metastasis. Finally mir-21 can be used as a predictive ofpoor prognosis for OSCC so can be on the path of cure the disease has been faster progress. Mir-21 is recommended for other drugs that could inhibit, such as CI-1033 to examine from drugbank for OSCC, it is part of effective drugs against cancer.