Synthesize of PLGA microspheres; optimization of experimental parameters

In this study, PLGA microspheres were fabricated through an oil-in-water (O/W) single emulsion technique and the influence of two parameters; namely volume ratio of organic/aqueous phase and emulsifier concentration, on size distribution of the microspheres was examined. Particle size and morphology of the microspheres were studied using scanning electron microscopy. The emulsion containing 1w/v% polyvinyl alcohol with an organic to aqueous phase ratio of 1:15 produced microspheres of 1 to 20 μm with the most uniform size distribution