Adhesive Topical Anti-Acne Patch;Preparation and Performance Evaluation

The dermal cosmetic patch is a new cosmetic technology for treating acne. The objective of this study is a physicochemical evaluation of salicylic acid formulated in the adhesive topical anti-acne patch (ATAP) and to investigate in vitro kinetics of release of salicylic acid from the adhesive film. Fifteen different formulations of ATAPs were prepared using casting technique. The prepared ATAPs were analyzed by different tests such as thickness, phase separation, surface roughness, peel strength, tackiness, and in vitro drug release. Compatibility between polymer and drug was investigated by FTIR. The maximum drug release in 8 hours for selected formulation was 1.2% of the loaded salicylic acid. Considering Higuchi s model, linear relation between the amount of released drug and the square root of time with a correlation coefficient of 0.99 were observed. The release profile and adhesion properties showed good behavior for the water-based acrylic emulsion as a well-considered drug carrier