Electrospun Poly-ε-Caprolactone/Poly (Propylene Imine) Dendrimer Nanofiber Mats (PCl/PPI) as an Effective Drug Delivery System

Ibuprofen (IBU) intercalated mats of poly-ε-caprolactone/poly (propylene imine) dendrimer at second generation (PCL/PPI) nanofibers were prepared using electrospinning process in order to compare its drug release characteristics with dendrimer-free as-spun PCl nanofibers. Effects of solvent and IBU presence on the fiber morphology were discussed by analysis of scanning electron micrographs. The amount of drug released from drug-loaded (PCL/PPI) nanofibers in comparison with dendrimer-free PCl nanofibers were measured using a UV-spectrophotometer during 24 hours. Lastly, drug-loaded (PCL/PPI) nanofibers exhibited much better release characteristics than drug suspensions without PPI dendrimer due to the sustained release property of (PCL/PPI) composite