New potential for biomedical applications of viologen-phosphorus dendrimers

In this paper we summarize the results of several years of work related to the application of new polymeric polycationic groups- viologen dendrimers. Dendrimers are known since the 80’s. Nevertheless, it has not yet found wide use in medicine. One of the features that obstruct the use of dendrimers in medicine is their quite high toxicity. The solution of this problem may be to synthesis new small dendrimers, which do not carry positive charges outside the moiety, but they are located inside the molecules. Results from these studies show that these dendrimers can have applications to cure many diseases, such as cancer or neurodegenerative diseases. They have also antimicrobial properties and they can form complexes with siRNA, which make them a tool in transfection of genetic material

Keywords:

Dendrimers , Polycationic polymers , Viologens , Biomedical application , Neurodegenerative diseases