Preparation of Antibacterial Wound Dressing Membranes based on Chitosan and Multifunctional Epoxy Crosslinkers with Build-in Quaternary Ammonium Salts

Wound dressings are an important part of the pharmaceutical and treatment care of wounds. Effective wound dressings not only require protecting the wound from surroundingenvironments, but also promote the healing process through providing a moist environment, allow continuous tissuereconstruction, and protect wound from microbial infection.[1]. Nowadays, wound dressings based on bio-resource materials such as alginate, hyaluronic acid, collagen andchitosan have been attracted wide interest due to their good biocompatibility and healing properties. In this regard,chitosan have been shown the better performance for wounddressing application [1]. However, wound dressings based on chitosan have boundaries such as low mechanical propertiesand weak antibacterial activity. Therefore, several attempts have been carried out to improve the mechanical andantibacterial properties of the chitosan [1]. In the present work, some epoxy-based crosslinkers with and without quaternary ammonium salts (QAS) were synthesizedand used for partially and fully crosslinking of chitosan. The mechanical, physical and biological properties of the preparedmembrane were studied and the feasibility of these new materials for potential wound dressing application was evaluated.