One-pot synthesis of 3,3 -(hexane-1,6-diyl)bis(5,5-disubstituted spiro and none spiroimidazolidine-2,4-diones): A bis-drug capability

An improved versatile method was applied for preparation of several new 3,3 -(hexane-1,6-diyl)bis(5,5-disubstituted spiro and none spiroimidazolidine-2,4-diones) or bis-hydantoins. In this process some ketones and aldehydes were converted to several hydantoins effectively. These hydantoins, in the presence of hexamethylene dibromide, dual alkylated and incorporated to bis-imidazolidine-2,4-diones in one step. The reactions ran click chemically and remarkable yields were achieved. The resulted compounds, to our knowledge will potentially have bis-drug behavior in comparison to mono-counterparts, as previously reported for comparable heterocycles in the literature. Spectral analysis confirmed the structures of synthesized bis-imidazolidine-2, 4-diones.

Keywords:

Imidazolidine-2 , 4-dion , Hydantoin , Bis-hydantoin , Bis-drug , Antiepileptic , Spirohydantoin