SYNTHESIS OF AN INORGANIC HYDROGEL BASED ON STARCH AND GELATIN VIA SCHIFF BASE REACTION

Polysaccharide-based hydrogels are remarkable materials for the biomedical fields becauseof its excellent biodegradation and biocompatibility. In this work, a novel polysaccharide-basedhydrogel was fabricated by in situ crosslinking of starch and gelatin. Starch was oxidized withperiodate to produce aldehyde groups. The reaction takes place through the formation of Schiff basesbetween aldehyde groups of starch and amino groups of gelatin. The effect of various processparameters such as reaction time, reaction temperature, starch concentration, gelatin content andperiodic acid concentration on the efficacy of the crosslinking (aldehyde content) was investigated.

Keywords:

Hydrogel , Starch , Gelatin , Schiff base