THE RELEASE OF TETRACYCLINE HYDROCHLORIDE FROM THE POLYACRYLAMDE BASED NANOPOROUS HYDROGEL

In the present studies, the releases of tetracycline hydrochloride from the drug-loaded nanoporous hydrogels have been discussed, for the evaluation of the drug release mechanism and diffusion coefficients. It has been observed that diffusion exponent n has 0.68 value and gel characteristic constant k has 1.625x10 value, for the release of tetracycline hydrochloride in distilled water from the drug loaded hydrogels. Therefore, drug release from the drug loaded hydrogels through non-fickian or anomalous diffusion mechanism where the rate of drug diffusion and rate of polymer relaxation were comparable. The effect of pH on the release pattern of tetracycline has been studied by varying the pH of the release medium. However, in each release medium, the initial diffusion coefficient was observed to be more than the late time diffusion coefficient.

THE RELEASE OF TETRACYCLINE HYDROCHLORIDE FROM THE POLYACRYLAMDE BASED NANOPOROUS HYDROGEL Keywords:

Nanoporous hydrogel , tetracycline hydrochloride , polyacrylamide , release

THE RELEASE OF TETRACYCLINE HYDROCHLORIDE FROM THE POLYACRYLAMDE BASED NANOPOROUS HYDROGEL authors

GHASEM REZANEJAD BARDAJEE

Department of Chemistry, Payame Noor University, Qazvin Branch Qazvin, P.O. Box ۸۷۸, Iran University

ALI POURJAVADI

Polymer Research Laboratory, Department of Chemistry, Sharif University of Technology, Tehran, P.O. Box ۱ ۱۳۶۵-۹۵.۱۶, Iran

ROUHOLLAH SOLEYMANW

Polymer Research Laboratory, Department of Chemistry, Sharif University of Technology, Tehran, P.O. Box ۱۱۳۶۵-۹۵.۱۶, Iran

ZARi HOOSHYAR

Department of Chemistry, Payame Noor University, Qazvin Branch Qazvin, P.O. Box ۸۷۸, Iran University

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UFGNSM03_040

Index date: 1 July 2017

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REZANEJAD BARDAJEE, GHASEM and POURJAVADI, ALI and SOLEYMANW, ROUHOLLAH and HOOSHYAR, ZARi,1390,THE RELEASE OF TETRACYCLINE HYDROCHLORIDE FROM THE POLYACRYLAMDE BASED NANOPOROUS HYDROGEL,3rd International Conference on Ultrafine Grained and Nanostructured Materials ,Qarchak,https://civilica.com/doc/613068

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Type of center: پیام نور

Paper count: 100,744

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