KF/HNTS CATALYZED ONE-POT THREE-COMPONENT BIGINELLI REACTIONS: AN EFFICIENT YNTHESIS OF 3,4- DIHYDROPYRIMIDIN-2-(1H)-ONE
Publish place: 4th International Conference on Recent innovations in chemistry and chemical engineering
Publish Year: 1396
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
CHCONF04_098
تاریخ نمایه سازی: 8 آذر 1396
Abstract:
Potassium fluoride/Holloysite nonotube (KF/HNTs) acts an active hetrogeneos base catalyst for Biginelli reaction. Here wehave describe An efficient one-pot synthesis of 3,4- dihydropyrimidine-2(1H)-one via a three-component reaction ofaldehyde, urea, and β-ketoester in the presence of a catalytic amount of (KF/HNTs). The experimental results showed thatthe KF/HNTs had high catalytic activity and it can be recycled without significant loss of activity. This protocols exhibitadvantages such as excellent yield, easy work-up and eco-friendly conditions.
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Authors
Mercedeh Ghanei
Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran
Mohammad A Khalilzadeh
Department of Chemistry, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran
Mohammad Mahmoodi Hashemi
Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran
Issa Yavari
Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran