The role of sr-b1 receptor in cancers

This abstract discusses the significance of SR-BI as a diagnostic as well as prognostic indicator of cancer to help reveal the roles of this protein to cancer development, progression and survival. Scavenger Receptor Class B Type I (SR-BI) is a high density lipoprotein (HDL) receptor that simplifies the uptake of cholesterol esters from circulating lipoproteins. Further findings suggest a serious role for SR-BI in cholesterol metabolism, signaling, motility, and proliferation of cancer cells and therefore a potential main impact in carcinogenesis and metastasis. Furthermore, genomic data indicate that based on the type of cancer, high or low SR-B1 expression may endorse poor survival. A high expression of SR-B1 has been showed in a vast variety of malignant cell lines such as breast, prostate, ovarian, pancreatic, nasopharyngeal, and colorectal cancers. we did a search based on the keywords cancer AND SR-B1 in PubMed, EMBASE, Google Scholar databases.In human breast carcinoma, increasing SR-B1 protein levels were indicted in malignant tissue against cancer free surrounding tissue in xenograft investigations. Also, another study proved that over 50% of all inspected breast cancer tissue revealed a high expression of SR-B1 which significantly connected with larger size of the tumor, metastasis to lymph node, and overall decreased survival. Moreover, breast carcinomas showing higher SR-B1 mRNA and protein levels indicated enhanced accumulation of intratumor cholesteryl ester which related to aggressiveness and poor prognosis in patients. Similarly, knockdown of SR- B1significantly decreased tumor size in mouse models and reduced cell proliferation and migration in vitro. a reduction of SR-B1 was shown to moderate prostate-specific antigen (PSA) levels and cell practicality in prostate cancer cells. Furthermore, SR-B1 expression and enzymes complicated in the synthesis of androgens showed a positive correlation demonstrating that SR-B1 may have a potential function in establishing androgen independence. Additionally, in nasopharyngeal cancer (NPC) SR-B1 was overexpressed in 75% of clinical NPC samples and all inspected NPC cell lines though SR- B1 expression was lower in surrounding non-malignant epithelial cells proposing SR-B1 as a possible biomarker of NPC. Due to the increasing incidence of different cancers, the need to discover a new medication therapeutic with more efficacy and fewer side effects is felt, so we can be used SR-B1 according to the potential effects of it for treat varying types of cancer

Keywords:

Breast Cancer , Prostate Cancer , Lung Cancer , Cervical Cancer , Cancer Diagnosis , Cancer Genetics