Examining the expression of the protein in gpx-1 breast cancer tissue cells

The most common type of cancer among women is breast cancer, which is always a serious threat to all ages. In general, factors such as the age of the person, the first child, the birth of the first child, the use of contraceptives, people with low activity, inactive people and overweights are involved in the process of breast cancer. According to statistics, only 5 to 10% of cases of breast cancer are affected by the transmission of genetic factors. This GPX-1 protein is produced by people of the same genome, including gene proteins which act as an enzyme for glutathione peroxidase and is effective ineliminating intracellular free radicals. As you know, glutathione peroxidase of a selenoprotein has a direct relationship with breast cancer, which is associated with an increase in the amount of selenium enzyme activity, the risk factors for breast cancer also increase. This is due to the displacement of amino acids 5 alanine and the replacement of amino acids 6 and 7 of alanine in the position of 198proteins of leucine. While changing the position of selenocysteine in the active site of the enzyme, we always we see a decrease in the activity of the enzyme, which explains the association between theexpression of this protein and the development of cancer. The change in the position of selenocysteine in the active site of SKBR3 in the GPX-1 cells of the enzyme and subsequent reduction of the enzyme s specific activity and, on the other hand, the developed expression to GPX-1 under repression treatment, confirms the meaningful induction of apoptosis. Therefore, there would be the title of a drugtarget in the process of treating this disease

Keywords:

Breast Cancer , Gene and Cancer , Cell and Cancer , Cancer Risks , Cancer Genetics , Cancer Treatment and Management