An assessment of the toxicity of carbon dot nanoparticles to Pichia pastoris
Publish place: International Conference/Workshop of Inter-Islamic Network on Nanotechnology (INN) on Nanotechnology and Nanomedicine
Publish Year: 1396
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
NTNM01_019
تاریخ نمایه سازی: 7 اسفند 1396
Abstract:
The excellent physical and chemical properties of carbon dots (CDs) such as their extra small size, large surface-to-volume ratio, inherent fluorescence, etc. provides them great potential in many biomedical applications. However, their biosafety issues are still indistinct. In the present study, the toxicity of CDs to a unicellular eukaryotic model organism was investigated. The CDs were prepared through pyrolysis of citric acid and characterized by means of dynamic light scattering (DLS), UV-vis spectrophotometry and spectrofluorimetry. Results show that the synthesized CDs have blue emission around 470 nm and the mean diameter of CDs was obtained to be 3.1±0.4 nm. Moreover, addition of CDs to the culture medium revealed dose-dependent toxicity to Pichia pastoris.
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Authors
Zahra Hallaji
Protein Research Center, Shahid Beheshti University, Tehran, Iran
Zeinab Bagheri
Protein Research Center, Shahid Beheshti University, Tehran, Iran
Hamide Ehtesabi
Protein Research Center, Shahid Beheshti University, Tehran, Iran
Moones Rahmandoust
Protein Research Center, Shahid Beheshti University, Tehran, Iran