Acute zinc intoxication: Synthesis and clinical evaluation of 2-(2-(2-aminophenyl) disulfanyl) benzenamine for removal of zinc ions in rats
Publish Year: 1388
نوع سند: مقاله کنفرانسی
زبان: English
View: 2,357
This Paper With 6 Page And PDF Format Ready To Download
- Certificate
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
CHEMISTRYMED01_177
تاریخ نمایه سازی: 30 فروردین 1388
Abstract:
An experiment was performed using male rats to investigate the effect and ability of 2-(2-(2-aminophenyl)
disulfanyl) benzenamine (L1) to remove zinc ions from blood and body organs following the administration of
zinc chloride. Two groups of rats were given zinc orally at a daily dose of 40 and 60 mg Zn+2 /kg body weight for
60 days. After this period, all the rats that were administered to zinc were severely anemic and showed toxicity
symptoms through an increase in zinc and a decrease in iron level in blood and certain organs. The ability of 2-
(2-(2-aminophenyl) disulfanyl) benzenamine (L1) to remove zinc has been investigated by injecting of this chelator to the rats for one week. The results showed that the zinc level existent in the blood and organs was significantly reduced and, at the same time, the iron concentration returned to the normal level. By this investigation we onclude that treatment with L1 at the given dose rate is safe to be used for chelation in zinc excessively loaded rats and can remove this ion from the body.
Keywords:
Authors
Sheyda Ahmadi
Department of Chemistry, Shahid Bahonar University of Kerman, kerman-Iran
Sheiva ahmadi
School of Chemistry, University College of Science, University of shahrood, shahrood-Iran
S. Jamilaldin Fatemi
Department of Chemistry, Shahid Bahonar University of Kerman, kerman-Iran
Alireza Badiei
School of Chemistry, University College of Science, University of Tehran, Tehran-Iran
مراجع و منابع این Paper:
لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :