Different Presentation of Treatment in Carcinomatous Meningitis of Breast Cancer: Report of 3Cases

Leptomeningeal metastasis refers to the multifocal seeding of the leptomeninges by malignant cells. Carcinomatous Meningitis (CM) occurs in approximately 5% of patients with breast cancer. Herein, we suggest that IT can use in treatment of breast cancer patients with CM before of anytreatment until can prevent of going patient to debilitating phase of this disease. Patients and Methods: Three patients with high risk breast cancer with leptomeningeal metastasis: A 62 year-old Kurdish woman with a history of lung tuberculosis. Her cerebrospinal fluid was positive formalignant cells. She treated with intrathecal chemotherapy and died 3 months after diagnosis of CM. In cerebrospinal fluid (CSF) analysis with diagnosis of CM treated with brain irradiation and multiple courses of intrathecal chemotherapy. After six months she is well still and in follow up now. She treated with intrathecal chemotherapy and she is alive yet. Conclusion: According to the poor prognosis of this disease it is better that in high risk breast cancer patients like NHL high risk patients IT prophylaxis was done for these high risk because by this way, we can prevent of going patient to debilitating phase of this disease

Keywords:

Breast Cancer , Carcinomatous Meningitis , Intrathecal Chemotherapy