Vitamin D and Breast Cancer, Is there any association

Vitamin D is one of the fat solution vitamins that play important roles in immunity system adjusted, genes expression and antioxidant function. Breast cancer is one of the common cancer in women population that has much mortality and debility in every year. Vitamin D deficiency is verycommon in human and the last study of clinical nutrition show that more of disease is relationship between vitamin D deficiency and incidence of chronic disease. In this article we review last of clinical trial study to investigated between vitamin D and breast cancer Method: This review article is with search in PUBMED motor with keyword vitamin D , 25 hydroxy vitamin D and Breast Cancer between 2008-2014. In this search only articles that were Clinical Trial, were selected and investigated 12 article for this review. Result: Results of this article are included:Vitamin D and immunity system: Function of vitamin D in immunity system and adjusted of immune cell is known and clear. Effect of vitamin D in prevention of cancers, autoimmunity disease and allergy is with adjusted of immune system. In 3 studies protective effect of vitamin D after treatment of breast cancer with improvement of immunity system were shown. Vitamin D and adjusted of gene expression of hormone receptor:Some of study had shown that vitamin D can play an important role in gene expression and hormone receptor; also the control of estrogen receptor was one of function of vitamin D that studies were suggested vitamin D supplement in treatment of breast cancer. Vitamin D receptor polymorphism in patient with breast cancer: One of common status of vitamin D in women with breast cancer is polymorphism of vitamin D receptor (VDR) that had observed in some of studies. Discussion and Conclusion: Vitamin D deficiency is very common in human population that was made elevate of chronic disease incidence. Autoimmune disease, allergy and cancer are chronic disease that immune system is involved.Last observation has shown that vitamin D play an important role in control of estrogen receptor gene expression and insufficient intake of vitamin D or vitamin D receptor polymorphism are common in patients with breast cancer that suggested intake of vitamin D food source or supplements for prevention of breast cancer.

Keywords:

vitamin D , 25 hydroxy vitamin D , Breast Cancer