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in-silico analysis of hsa-mir-146a targetome pathway and its SNP function in patients with breastcancer: probable association between alleles and prognosis

تعداد صفحات: 1 | تعداد نمایش خلاصه: 93 | نظرات: 0
سال انتشار: 1393
کد COI Paper: ICBCMED10_107
زبان Paper: Englishglish
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مشخصات نویسندگان Paper in-silico analysis of hsa-mir-146a targetome pathway and its SNP function in patients with breastcancer: probable association between alleles and prognosis

Mahboobeh Meshkat - Division of cellular and molecular biology, Department of biology, Nourdanesh University ofMeymeh, Meymeh, Isfahan, Iran
Hamzeh Mesrian Tanha - Department of Biology, Faculty of Science, University of Isfahan, Isfahan, Iran
Kamran Ghaedi - Zistfanavari Novin biotechnology institute, Isfahan, Iran
Mansoureh Azadeh - Zistfanavari Novin biotechnology institute, Isfahan, Iran

چکیده Paper:

Background: According to the World Health Organization, breast cancer is the most common diagnosed cancer in women. MicroRNAs (miRNAs) are causing tremendous excitement in cancer research. miRNAs have been shown to regulate oncogenes, tumor suppressors and a number of cancerrelated genes. mir-146a is a tumor suppressor miRNA proposed as a biomarker in breast cancer. Objective: the aim of our study is to expand current knowledge about molecular function of miR-146a and a potential biomarker in breast tumor cells by using bioinformatics tools.Methods: validated and predicted targets of miR-146a were obtained from miRtarbase and miRwalk databases. UniGene and DAVID databases were used for further analysis. MIRSNP database predicts single nucleotide polymorphism in miR-146a and its function. Results: Our data manifested KEGG signaling pathways pathway in cancer as the most statistical relevant pathway with miR-146a targetome. Interestingly, it revealed that miR-146a inhibit some important breast cancer-related pathways such as TGFβRІ, PDGF by targeting some well-knownoncogenes such as SMAD2/3, SMAD4, PDGFR. rs2910146 is located in mir-146a seed. It is predicted that G allele could increase stability of the stem-loop structure of mir-146a. Conclusion: According to our data miR-146a may be related to breast cancer through targeting itstargetome leading to proliferation, invasion, migration and evading apoptosis in breast cancer. Therefore hsa-mir-146a is a potential tumor suppressor miRNA which could be used as worthwhile prognostic biomarker. Allele G in the SNP could have good prognostic value for breast cancer centers due to its effect on mir-146a stability.

کلیدواژه ها:

Breast cancer, miR-146a, SNP, targetome, signaling pathway

کد Paper/لینک ثابت به این Paper

برای لینک دهی به این Paper می توانید از لینک زیر استفاده نمایید. این لینک همیشه ثابت است و به عنوان سند ثبت Paper در مرجع سیویلیکا مورد استفاده قرار میگیرد:

https://civilica.com/doc/726545/

کد COI Paper: ICBCMED10_107

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در صورتی که می خواهید در اثر پژوهشی خود به این Paper ارجاع دهید، به سادگی می توانید از عبارت زیر در بخش منابع و مراجع استفاده نمایید:
undefined, undefined و undefined, undefined و undefined, undefined و undefined, undefined,1393,in-silico analysis of hsa-mir-146a targetome pathway and its SNP function in patients with breastcancer: probable association between alleles and prognosis,دهمین کنگره بین المللی سرطان پستان,Tehran,,,https://civilica.com/doc/726545

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برای بار اول: (1393, Meshkat, Mahboobeh؛ Hamzeh Mesrian Tanha و Kamran Ghaedi و Mansoureh Azadeh)
برای بار دوم به بعد: (1393, Meshkat؛ Mesrian Tanha و Ghaedi و Azadeh)
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